autologous anti-CD19 CAR-IL-18-expressing T lymphocytes

{
  "id": "MLC-T-ONC-011368",
  "term": "autologous anti-CD19 CAR-IL-18-expressing T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19), and expressing the pro-inflammatory cytokine interleukin 18 (IL-18), with potential antineoplastic activity. Upon intravenous administration, autologous anti-CD19 CAR-IL-18-expressing T lymphocytes target, bind to, and induce selective toxicity in CD19-expressing tumor cells. IL-18 promotes T-cell persistence and potentiates the immune response against tumor cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors. Incorporation of costimulatory signaling domains increases human T-cell function, expansion, and survival.",
  "synonyms": [
    "huCART19-IL18",
    "autologous anti-CD19 CAR IL-18-expressing T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd19-car-il-18-expressing-t-lymphocytes/"
}