autologous anti-CD19 CAR-T cells CABA-201

{
  "id": "MLC-T-ONC-011369",
  "term": "autologous anti-CD19 CAR-T cells CABA-201",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the B-lymphocyte antigen CD19, coupled to a costimulatory domain of 4-1BB (CD137), with potential immunomodulatory activity. Upon administration, autologous anti-CD19 CAR-T cells CABA-201 target and bind to CD19-expressing B cells. This results in a cytotoxic T-lymphocyte (CTL) response against CD19-expressing B cells. CD19, a B-cell-specific cell surface antigen that plays an important role in B-cell activation, is overexpressed in some autoimmune diseases.",
  "synonyms": [
    "autologous anti-CD19 CAR T cells CABA-201",
    "autologous CD19-specific chimeric antigen receptor T cells CABA-201"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd19-car-t-cells-caba-201/"
}