monoclonal antibody Mono-dgA-RFB4

{
  "id": "MLC-T-ONC-015271",
  "term": "monoclonal antibody Mono-dgA-RFB4",
  "field": "Oncology and biomedicine",
  "definition": "An immunotoxin of monoclonal antibody (MoAb) RFB4 covalently linked to a single deglycosylated ricin toxin A-chain (dgA), originated from castor beans. MoAb RFB4 recognizes CD22 antigen, a B-cell adhesion protein expressed on malignant cells in about 70 percent of non-Hodgkin lymphoma and chronic lymphocytic leukemia. Ricin toxin A-chain, a potent protein synthesis inhibitor, was deglycosylated and was used in this immunoconjugate to avoid hepatic entrapment. This agent limits specific cytotoxicity of ricin toxin to CD22-positive malignant cells.",
  "abbreviation": "MONO dgA RFB4",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/monoclonal-antibody-mono-dga-rfb4/"
}