muromonab-CD3

{
  "id": "MLC-T-ONC-005592",
  "term": "muromonab-CD3",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.",
    "A murine IgG2a monoclonal antibody with immunosuppressive activity. Muromonab-CD3 binds to and inhibits CD3 on the surface of circulating T-lymphocytes; binding of muromonab-CD3 to CD3-positive T cells results in an early activation of this T cell subset, followed by cytokine release, and subsequently inhibition of T cell functions. This agent may cause the opsonization and elimination of CD3-positive T cells from the circulation by mononuclear phagocytes in the liver and spleen. CD3 is part of the functional T cell receptor (TCR) complex, which is necessary for antigen recognition by T cells, and is required for signal transduction."
  ],
  "abbreviation": "MOAB OKT3",
  "synonyms": [
    "monoclonal antibody OKT3",
    "Anti-CD3 monoclonal antibody OKT3",
    "MOAB OKT3",
    "OKT3"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/muromonab-cd3/"
}