ertumaxomab

{
  "id": "MLC-T-ONC-013424",
  "term": "ertumaxomab",
  "field": "Oncology and biomedicine",
  "definition": "A murine monoclonal antibody with two antigen-recognition sites: one for CD3, an antigen expressed on mature T cells, and one for HER-2-neu, a tumor-associated antigen that promotes tumor growth. Ertumaxomab attaches to CD3-expressing T cells and HER-2-neu-expressing tumor cells, selectively cross-linking tumor and immunologic cells which results in the recruitment of cytotoxic T cells to the T cell/tumor cell aggregate.",
  "abbreviation": "CD3-HER2neu MOAB",
  "synonyms": [
    "anti-CD3 x anti-HER-2-neu bispecific monoclonal antibody",
    "MOAB anti-CD3 x anti-HER-2-neu"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ertumaxomab/"
}