engineered interferon ORB-011

{
  "id": "MLC-T-ONC-013345",
  "term": "engineered interferon ORB-011",
  "field": "Oncology and biomedicine",
  "definition": "An attenuated, cis-targeted interferon (IFN), with potential immunostimulating and antineoplastic activities. Upon administration, engineered IFN ORB-011 specifically targets, binds to and activates type 1 conventional dendritic cell (cDC1). As these are specific immune cells that specialize in presenting tumor antigens to, and activating, tumor cytotoxic CD8 T cells, ORB-011 may be able to stimulate a specific cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response. ORB-011 is engineered in such a way as to minimize off-target IFN-based binding and thereby avoiding systemic toxicity.",
  "synonyms": [
    "cis-targeted interferon ORB-011",
    "engineered cytokine ORB-011",
    "engineered IFN ORB-011"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/engineered-interferon-orb-011/"
}