Enzalutamide

{
  "id": "MLC-T-ONC-002865",
  "term": "Enzalutamide",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat certain types of prostate cancer. It is also being studied in the treatment of other types of cancer. Enzalutamide binds to proteins called androgen receptors, which are found in some prostate cancer cells. These proteins bind to androgens (male hormones) and may cause cancer cells to grow. Enzalutamide blocks these proteins and may keep cancer cells from growing. It is a type of antiandrogen. Also called Xtandi.",
    "An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance."
  ],
  "synonyms": [
    "Xtandi",
    "selective androgen receptor modulator MDV3100"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/enzalutamide/"
}