ERK 1/2 inhibitor ASTX029

{
  "id": "MLC-T-ONC-013411",
  "term": "ERK 1/2 inhibitor ASTX029",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of the extracellular signal-regulated kinases (ERK) 1 and 2, with potential antineoplastic activity. Upon administration, ASTX029 specifically binds to and inhibits both ERK 1 and 2, thereby preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The MAPK/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in the proliferation, differentiation and survival of tumor cells.",
  "synonyms": [
    "extracellular signal-regulated kinase 1/2 inhibitor ASTX029",
    "extracellular signal-regulated kinase inhibitor ASTX029",
    "ERK inhibitor ASTX029"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/erk-1-2-inhibitor-astx029/"
}