ERK1/2 inhibitor KO-947

{
  "id": "MLC-T-ONC-013421",
  "term": "ERK1/2 inhibitor KO-947",
  "field": "Oncology and biomedicine",
  "definition": "An inhibitor of the extracellular signal-regulated kinases (ERK) 1 and 2, with potential antineoplastic activity. Upon intravenous administration, KO-947 specifically binds to and inhibits both ERK 1 and 2, thereby preventing the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The MAPK/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in the proliferation, differentiation and survival of tumor cells.",
  "synonyms": [
    "extracellular signal-regulated kinase 1/2 inhibitor KO-947",
    "ERK inhibitor KO-947"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/erk1-2-inhibitor-ko-947/"
}