Ravoxertinib

{
  "id": "MLC-T-ONC-016373",
  "term": "Ravoxertinib",
  "field": "Oncology and biomedicine",
  "definition": "An orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, ravoxertinib inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.",
  "synonyms": [
    "ERK inhibitor GDC-0994"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ravoxertinib/"
}