Erlotinib hydrochloride

{
  "id": "MLC-T-ONC-002955",
  "term": "Erlotinib hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used alone to treat certain types of non-small cell lung cancer and with gemcitabine hydrochloride to treat certain types of pancreatic cancer. It is also being studied in the treatment of other types of cancer. Erlotinib hydrochloride blocks a protein called EGFR, which may help keep cancer cells from growing. It is a type of tyrosine kinase inhibitor. Also called CP-358,774, OSI-774, and Tarceva.",
    "The hydrochloride salt of a quinazoline derivative with antineoplastic properties. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation."
  ],
  "synonyms": [
    "CP-358,774",
    "OSI-774",
    "Tarceva"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/erlotinib-hydrochloride/"
}