Estramustine phosphate sodium

{
  "id": "MLC-T-ONC-013438",
  "term": "Estramustine phosphate sodium",
  "field": "Oncology and biomedicine",
  "definition": "The orally available disodium salt, monohydrate, of estramustine phosphate, a synthetic molecule that combines estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects.",
  "synonyms": [
    "estramustine phosphate",
    "estramustine sodium phosphate"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/estramustine-phosphate-sodium/"
}