FGFR inhibitor1/2/3 HMPL-453

{
  "id": "MLC-T-ONC-013581",
  "term": "FGFR inhibitor1/2/3 HMPL-453",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Upon administration, FGFR inhibitor HMPL-453 binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases (RTKs) upregulated in many tumor cell types, plays a key role in cellular proliferation, migration and survival.",
  "synonyms": [
    "FGFR inhibitor HMPL-453"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fgfr-inhibitor1-2-3-hmpl-453/"
}