FGFR1/2/3 inhibitor TYRA-200

{
  "id": "MLC-T-ONC-013583",
  "term": "FGFR1/2/3 inhibitor TYRA-200",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of the tyrosine kinase fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Upon oral administration, FGFR1/2/3 inhibitor TYRA-200 targets, binds to and inhibits FGFR1/2/3, and is specifically active against certain FGFR2 fusions, molecular brake and gatekeeper resistance mutations. This may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases (RTKs), is upregulated in many tumor cell types.",
  "synonyms": [
    "FGFR inhibitor TYRA-200"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fgfr1-2-3-inhibitor-tyra-200/"
}