FGFR2/3 inhibitor CGT4859

{
  "id": "MLC-T-ONC-013586",
  "term": "FGFR2/3 inhibitor CGT4859",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable reversible inhibitor of fibroblast growth factor receptor (FGFR) types 2 and 3 (FGFR2/3), with potential antineoplastic activity. Upon oral administration, FGFR2/3 inhibitor CGT4859 targets, reversibly binds to and inhibits FGFR2/3, and is specifically active against FGFR2 molecular brake and gatekeeper resistance mutations. This blocks FGFR2/3-mediated signaling and leads to an inhibition of tumor cell proliferation in FGFR2/3-overexpressing cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation, cell survival and angiogenesis.",
  "synonyms": [
    "FGFR2/FGFR3 inhibitor CGT4859"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fgfr2-3-inhibitor-cgt4859/"
}