FGFR2 inhibitor 3HP-2827

{
  "id": "MLC-T-ONC-013584",
  "term": "FGFR2 inhibitor 3HP-2827",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable small molecule inhibitor of fibroblast growth factor receptor 2 (FGFR2), with potential antineoplastic activity. Upon oral administration, FGFR2 inhibitor 3HP-2827 targets, binds to and inhibits FGFR2, which results in the inhibition of FGFR2-mediated signal transduction pathways. This may inhibit the proliferation of tumor cells that harbor FGFR2 alterations, including amplifications, mutations and fusions. FGFR2, a receptor tyrosine kinase upregulated and mutated in many tumor cell types, plays a key role in cellular proliferation, migration and survival.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fgfr2-inhibitor-3hp-2827/"
}