pan-FGFR inhibitor ABSK-121-NX

{
  "id": "MLC-T-ONC-015789",
  "term": "pan-FGFR inhibitor ABSK-121-NX",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable, small molecule pan-inhibitor of fibroblast growth factor receptor (FGFR) family proteins, with potential antineoplastic activity. Upon oral administration, pan-FGFR inhibitor ABSK-121 binds to and inhibits FGFR family proteins, including FGFR2 and FGFR3 gatekeeper, molecular brake, and activation loop mutations. This prevents FGFR-mediated signaling, and inhibits both tumor angiogenesis and proliferation of FGFR-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation, cell survival and angiogenesis.",
  "synonyms": [
    "FGFR inhibitor ABSK-121",
    "pan-fibroblast growth factor receptor inhibitor ABSK-121"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pan-fgfr-inhibitor-absk-121-nx/"
}