pan-FGFR inhibitor LY2874455

{
  "id": "MLC-T-ONC-015790",
  "term": "pan-FGFR inhibitor LY2874455",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable pan-inhibitor of fibroblast growth factor receptor (FGFR) family proteins, with potential antineoplastic activity. Upon oral administration, FGFR inhibitor LY2874455 binds to and inhibits FGFR subtypes 1 (FGFR1), 2 (FGFR2), 3 (FGFR3) and 4 (FGFR4), which results in the inhibition of FGFR-mediated signal transduction pathways. This inhibits both tumor angiogenesis and proliferation of FGFR-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation, cell survival and angiogenesis.",
  "synonyms": [
    "pan fibroblast growth factor receptor inhibitor LY2874455",
    "pan FGFR inhibitor LY2874455"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pan-fgfr-inhibitor-ly2874455/"
}