FLT3 inhibitor FF-10101 succinate

{
  "id": "MLC-T-ONC-013627",
  "term": "FLT3 inhibitor FF-10101 succinate",
  "field": "Oncology and biomedicine",
  "definition": "The succinate salt form of FF-10101, a FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2) inhibitor, with potential antineoplastic activity. Upon administration of FLT3 inhibitor FF-10101 succinate (FF-10101-01), FF-10101 irreversibly binds to and inhibits the activity of FLT3. This inhibits the proliferation of FLT3-expressing cancer cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias.",
  "synonyms": [
    "FF-10101 succinate",
    "FF10101 Succinate"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/flt3-inhibitor-ff-10101-succinate/"
}