Autologous anti-FLT3 CAR T cells AMG 553

{
  "id": "MLC-T-ONC-011429",
  "term": "Autologous anti-FLT3 CAR T cells AMG 553",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes genetically engineered with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-FLT3 CAR T cells AMG 553 target and bind to tumor cells expressing FLT3, which results in the cytotoxic T-lymphocyte (CTL)-mediated cell killing of FLT3-expressing tumor cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias (AMLs).",
  "synonyms": [
    "autologous FLT3 CAR-T cells AMG 553",
    "autologous anti-FLT3 CAR T lymphocytes AMG 553"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-flt3-car-t-cells-amg-553/"
}