FLT3 inhibitor HM43239

{
  "id": "MLC-T-ONC-013628",
  "term": "FLT3 inhibitor HM43239",
  "field": "Oncology and biomedicine",
  "definition": "A selective, reversible type I inhibitor of FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2) with potential antineoplastic activity. Upon administration of FLT3 inhibitor HM43239, it reversibly binds to and inhibits the activity of FLT3. This inhibits the proliferation of FLT3-expressing cancer cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias.",
  "synonyms": [
    "FMS-like tyrosine kinase 3 inhibitor HM43239"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/flt3-inhibitor-hm43239/"
}