fluorine F 18-fluoroazomycin arabinoside

{
  "id": "MLC-T-ONC-013718",
  "term": "fluorine F 18-fluoroazomycin arabinoside",
  "field": "Oncology and biomedicine",
  "definition": "A radiofluorinated 2-nitroimidazole derivative with hypoxia-specific tracer activity. Fluorine F 18-fluoroazomycin arabinoside is reduced under hypoxic conditions and is often seen in various malignant tumors, forming highly reactive intermediates. In its reduced form, fluorine F 18-fluoroazomycin arabinoside covalently binds to macromolecules, thereby accumulating in hypoxic cells and allowing radioisotopic imaging of these particular cells. Compared to fluorine F 18-misonidazole, fluorine F 18-fluoroazomycin arabinoside has a lower octanol:water partition coefficient; it therefore has less tendency to accumulate in lipophilic tissues and exhibits a faster renal clearance, leading to an improved imaging ability of hypoxic tissue.",
  "abbreviation": "18F-FAZA",
  "synonyms": [
    "18F-fluoroazomycin arabinoside"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fluorine-f-18-fluoroazomycin-arabinoside/"
}