18F-fluoromisonidazole

{
  "id": "MLC-T-ONC-000025",
  "term": "18F-fluoromisonidazole",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A radioactive substance being studied as an imaging agent in head and neck cancer and other types of cancer. It binds to large molecules in cancer cells that have a low level of oxygen. Radiation given off by 18F-fluoromisonidazole is detected by a positron emission tomography (PET) scan. Knowing the amount of 18F-fluoromisonidazole in the cancer cells may help plan the best treatment and help predict whether the cancer will come back after treatment. Also called 18F-MISO, fluorine F 18-fluoromisonidazole, and FMISO.",
    "A radiofluorinated 2-nitroimidazole derivate with hypoxia-specific tracer activity. Misonidazole is reduced under hypoxic conditions and in reduced form covalently binds to macromolecules in hypoxic cells. 18F (fluorine-18) radiofluorination of misonidazole to form 18F-fluoromisonidazole allows radioisotopic imaging of reduced misonidazole bound to macromolecules in hypoxic cells."
  ],
  "abbreviation": "18F-FMISO",
  "synonyms": [
    "18F-MISO",
    "fluorine F 18-fluoromisonidazole",
    "FMISO",
    "18F-misonidazole"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/18f-fluoromisonidazole/"
}