formoterol fumarate/roxithromycin

{
  "id": "MLC-T-ONC-013754",
  "term": "formoterol fumarate/roxithromycin",
  "field": "Oncology and biomedicine",
  "definition": "A combination preparation of the fumarate salt of a beta2-adrenergic receptor agonist and a macrolide antibiotic, with muscle-sparing and anti-cachexia effects. Formoterol appears to antagonize cachexia by reducing proteolysis mediated through the ubiquitin-protease pathway. Roxithromycin strongly inhibits inflammatory cytokine production and secretion from T cells and macrophages in vitro and in vivo. The combination exhibits a greater muscle sparing effect than either drug given individually at comparable doses.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/formoterol-fumarate-roxithromycin/"
}