Forodesine hydrochloride

{
  "id": "MLC-T-ONC-003325",
  "term": "Forodesine hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of some types of leukemia and lymphoma. It is a type of purine nucleoside phosphorylase (PNP) inhibitor. Also called BCX-1777.",
    "The hydrochloride salt of the synthetic high-affinity transition-state analogue forodesine. Forodesine binds preferentially to and inhibits purine nucleotide phosphorylase (PNP), resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively causes apoptosis in stimulated or malignant T-lymphocytes. A transition state analogue is a substrate designed to mimic the properties or the geometry of the transition state of reaction."
  ],
  "synonyms": [
    "BCX-1777",
    "immucillin-H"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/forodesine-hydrochloride/"
}