PNP-expressing ovine atadenovirus FP253

{
  "id": "MLC-T-ONC-016134",
  "term": "PNP-expressing ovine atadenovirus FP253",
  "field": "Oncology and biomedicine",
  "definition": "An ovine atadenovirus encoding E. coli purine nucleoside phosphorylase (PNP) with prodrug activating activity. Under the control of a prostate-directed promoter, PNP-expressing atadenovirus vaccine FP253 expresses PNP in prostate tissue only after intraprostatic administration; this enzyme catalyzes systemically administered fludarabine prodrug into the active agent, 2-fluoroadenine. Localized prodrug activation provides prostate-targeted chemotherapy, potentially reducing systemic side effects.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pnp-expressing-ovine-atadenovirus-fp253/"
}