Ocifisertib fumarate

{
  "id": "MLC-T-ONC-015583",
  "term": "Ocifisertib fumarate",
  "field": "Oncology and biomedicine",
  "term_source": "Ocifisertib Fumarate",
  "definition": "An orally available fumarate salt form of CFI-400945, a polo-like kinase 4 (PLK4) inhibitor with potential antineoplastic activity. Upon oral administration, polo-like kinase 4 inhibitor CFI-400945 selectively inhibits PLK4, which results in the disruption of mitosis and the induction of apoptosis. PLK4 inhibition also prevents cell division and inhibits proliferation of PLK4-overexpressing tumor cells. PLK4, a member of the polo family of serine/threonine kinases overexpressed in a variety of cancer cell types, plays a crucial role in the regulation of centriole duplication during the cell cycle.",
  "synonyms": [
    "CFI 400945 fumarate",
    "PLK4 inhibitor CFI-400945 fumarate",
    "polo-like kinase 4 inhibitor CFI-400945 fumarate"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ocifisertib-fumarate/"
}