Frameshift variant

{
  "id": "MLC-T-ONC-003341",
  "term": "Frameshift variant",
  "field": "Oncology and biomedicine",
  "definition": "An insertion or deletion involving a number of base pairs that is not a multiple of three, which consequently disrupts the triplet reading frame of a DNA sequence. Such variants (or mutations) usually lead to the creation of a premature termination (stop) codon, and result in a truncated (shorter-than-normal) protein product. Also called frameshift mutation.",
  "synonyms": [
    "frameshift mutation"
  ],
  "references": [
    "NCI Dictionary of Genetics Terms"
  ],
  "url": "https://mlchart.com/terminology/oncology/frameshift-variant/"
}