AIM2(-1)/HT001(-1)/TAF1B(-1) frameshift peptide vaccine

{
  "id": "MLC-T-ONC-009735",
  "term": "AIM2(-1)/HT001(-1)/TAF1B(-1) frameshift peptide vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine containing the three frame shift peptides (FSP) AIM2(-1), HT001(-1) and TAF1B(-1), with potential immunomodulating activity. Upon administration, the AIM2(-1)/HT001(-1)/TAF1B(-1) FSP vaccine may induce an immune response against microsatellite instability (MSI) colorectal cancer-associated antigens. Frame shift mutations of AIM2 (absent in melanoma 2, an interferon-inducible protein), HT001 (asteroid homolog 1 or ASTE1, with an unknown function) and TAF1B (TATA box-binding protein-associated RNA polymerase I B, a transcription factor) are seen in MSI-positive colorectal cancers and may be associated with malignant transformation, tumor progression and the presence of tumor-infiltrating lymphocytes. These FSPs all have one-base deletions.",
  "abbreviation": "AIM2(-1)/HT001(-1)/TAF1B(-1) FSP vaccine",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/aim2-1-ht001-1-taf1b-1-frameshift-peptide-vaccine/"
}