MSI

{
  "id": "MLC-T-ONC-005538",
  "term": "MSI",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A change that occurs in certain cells (such as cancer cells) in which the number of repeated DNA bases in a microsatellite (a short, repeated sequence of DNA) is different from what it was when the microsatellite was inherited. MSI may be caused by mistakes that don’t get corrected when DNA is copied in a cell. It is found most often in colorectal cancer, gastric cancer, and endometrial cancer, but it may also be found in many other types of cancer. Knowing whether a cancer has MSI may help plan the best treatment. Also called microsatellite instability.",
    "A characteristic of cells that contain an abnormality in DNA mismatch repair. The presence of MSI can be a marker of a germline pathogenic variant in one of the DNA mismatch repair genes, as in the case of Lynch syndrome. MSI can also occur sporadically. Also called microsatellite instability."
  ],
  "expansions": [
    "microsatellite instability"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "NCI Dictionary of Genetics Terms"
  ],
  "url": "https://mlchart.com/terminology/oncology/msi/"
}