Galactomannan derivative

{
  "id": "MLC-T-ONC-013812",
  "term": "Galactomannan derivative",
  "field": "Oncology and biomedicine",
  "definition": "A carbohydrate polymer composed of mannose and galactose, with chemotherapeutic enhancing activity. Galactomannan derivative binds to galectins on cell surfaces and may promote the transport of certain chemotherapeutics, such as 5-fluorouracil (5-FU), into tumor cells. This may increase the antineoplastic effect of 5-FU when administered concomitantly. Galectins are carbohydrate-binding proteins, upregulated on the surface of certain types of tumor cells, and may mediate cell association, survival and metastasis.",
  "abbreviation": "GD",
  "synonyms": [
    "1,4-beta-D-galactomannan"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/galactomannan-derivative/"
}