galectin-1 inhibitor OTX008

{
  "id": "MLC-T-ONC-013816",
  "term": "galectin-1 inhibitor OTX008",
  "field": "Oncology and biomedicine",
  "definition": "A calixarene-based compound and galectin-1 (Gal-1) inhibitor with potential anti-angiogenic and antineoplastic activities. Upon subcutaneous administration, galectin-1 inhibitor OTX008 binds Gal-1 which leads to Gal-1 oxidation and proteosomal degradation through a not yet fully elucidated mechanism, and eventually downregulates Gal-1. This decreases tumor cell growth and inhibits angiogenesis. Gal-1, a multifunctional carbohydrate-binding protein, is often overexpressed on tumor cells and plays a key role in cancer cell proliferation, apoptosis, tumor angiogenesis and evasion of immune responses.",
  "synonyms": [
    "Gal-1 inhibitor OTX008"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/galectin-1-inhibitor-otx008/"
}