galiximab

{
  "id": "MLC-T-ONC-003387",
  "term": "galiximab",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of follicular non-Hodgkin lymphoma. It binds to the protein CD80, which is found on certain normal white blood cells and on white blood cells that are cancer. It is a type of monoclonal antibody.",
    "A humanized IgG1 monoclonal antibody directed against CD80, the natural ligand for the T-cell antigen CD28 which mediates T-cell and B-cell adhesion. Galiximab binds to CD80 expressed on the cell surfaces of follicular lymphomas, resulting in antibody-dependent cell-mediated cytotoxicity (ADCC). CD80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes and is often expressed at low levels on the surfaces of follicular lymphoma cells and other lymphoid malignancies."
  ],
  "abbreviation": "MOAB IDEC-114",
  "synonyms": [
    "monoclonal antibody anti-CD80",
    "MOAB anti-CD80",
    "anti-B7-1",
    "anti-CD80"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/galiximab/"
}