galinpepimut-S

{
  "id": "MLC-T-ONC-013818",
  "term": "galinpepimut-S",
  "field": "Oncology and biomedicine",
  "definition": "A peptide cancer vaccine comprised of four peptide chains derived from the Wilms’ tumor gene 1 (WT1) protein, with potential immunomodulating and antineoplastic activities. Upon administration, galinpepimut-S, which is comprised of one WT1-derived peptide (WT-A1) that may stimulate CD8-positive T-cell responses; two WT1 peptides (WT1-427 long, WT1-331 long) that may stimulate CD4-positive T-cell responses; and one modified peptide (WT1-122A1 long) that may stimulate both CD4-positive and CD8-positive T cells, may elicit a targeted innate immune response against WT1-expressing tumor cells. WT1 protein, a zinc finger DNA-binding protein and transcription factor, is overexpressed in leukemic cells and in many non-hematological solid tumors.",
  "synonyms": [
    "WT-1 analog peptide vaccine SLS-001"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/galinpepimut-s/"
}