GCN2 modulator HC-7366-K

{
  "id": "MLC-T-ONC-013913",
  "term": "GCN2 modulator HC-7366-K",
  "field": "Oncology and biomedicine",
  "definition": "An immediate release (IR) capsule formulation of the potassium salt monohydrate form of HC-7366, a modulator of the serine/threonine protein kinase general control nonderepressible 2 (GCN2), with potential antineoplastic and immunomodulating activities. Upon oral administration, the base moiety HC-7366 of the GCN2 modulator HC-7366-K targets and binds to GCN2. This prevents GCN2 activity and GCN2-mediated signaling. This may induce apoptosis in tumor cells that rely on GCN2 signaling for survival. In addition, as GCN2 signaling reduces anti-tumor immunity, preventing GCN2 signaling may enhance anti-tumor immune responses. GCN2 plays a key role in the activation of the integrated stress response (ISR) pathway in response to amino acid deprivation and in hypoxic tumors.",
  "synonyms": [
    "general control nonderepressible 2 modulator HC-7366-K"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gcn2-modulator-hc-7366-k/"
}