GCN2 inhibitor APL-4098

{
  "id": "MLC-T-ONC-013912",
  "term": "GCN2 inhibitor APL-4098",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of the serine/threonine protein kinase general control nonderepressible 2 (GCN2; eukaryotic translation initiation factor 2-alpha kinase 4; GCN2 EIF2alpha kinase; eIF-2-alpha kinase GCN2), with potential antineoplastic and immunomodulating activities. Upon oral administration, GCN2 inhibitor APL-4098 specifically targets, binds to and inhibits the activity of GCN2. This prevents GCN2-mediated signaling and may induce apoptosis in tumor cells that rely on GCN2 signaling for survival. In addition, as GCN2 signaling reduces anti-tumor immunity, preventing GCN2 signaling may enhance anti-tumor immune responses. GCN2 plays a key role in the activation of the integrated stress response (ISR) pathway in response to amino acid deprivation and in hypoxic tumors.",
  "synonyms": [
    "general control nonderepressible 2 inhibitor APL-4098"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gcn2-inhibitor-apl-4098/"
}