MetAP2 inhibitor APL-1202

{
  "id": "MLC-T-ONC-015118",
  "term": "MetAP2 inhibitor APL-1202",
  "field": "Oncology and biomedicine",
  "definition": "An orally available inhibitor of methionine aminopeptidase II type (MetAP2) with potential antiangiogenic and antineoplastic activities. Upon administration, APL-1202 binds to and reversibly inhibits MetAP2, thereby preventing MetAP2-mediated signal transduction pathways. This may suppress endothelial cell growth and inhibit tumor angiogenesis, resulting in tumor cell death. MetAP2, a member of the dimetallohydrolase family, is upregulated in certain tumor cell types and plays a key role in angiogenesis, proliferation and survival.",
  "synonyms": [
    "methionine aminopeptidase type II inhibitor APL-1202"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/metap2-inhibitor-apl-1202/"
}