MLchartDataset catalogue

PPI-2458

Term · Oncology and biomedicine · MLC-T-ONC-016200

A synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class.

Table 1. Record
IdentifierMLC-T-ONC-016200
FieldOncology and biomedicine
ReferencesNational Cancer Institute Thesaurus (CC BY 4.0)
Record as JSON 
{
  "id": "MLC-T-ONC-016200",
  "term": "PPI-2458",
  "field": "Oncology and biomedicine",
  "definition": "A synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ppi-2458/"
}

Record 13,547 of 17,721 in Oncology and biomedicine terminology (MLC-0111). Request the full dataset.