Wnt signaling inhibitor APL-5125

{
  "id": "MLC-T-ONC-017565",
  "term": "Wnt signaling inhibitor APL-5125",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable small molecule kinase inhibitor of the Wnt signaling pathway, with potential antineoplastic activity. Upon oral administration, Wnt signaling inhibitor APL-5125 targets and binds to an as of yet undisclosed kinase in the Wnt signaling pathway, thereby preventing Wnt-mediated signaling. This may inhibit growth of tumor cells in which the Wnt signaling pathway is overactivated. The Wnt signaling pathway is upregulated in many cancers and plays a key role in tumor cell proliferation.",
  "synonyms": [
    "kinase inhibitor APL-5125"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/wnt-signaling-inhibitor-apl-5125/"
}