Porcupine inhibitor XNW7201

{
  "id": "MLC-T-ONC-016186",
  "term": "Porcupine inhibitor XNW7201",
  "field": "Oncology and biomedicine",
  "definition": "An orally available inhibitor of porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, PORCN inhibitor XNW7201 targets, binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational acylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. PORCN, a membrane-bound O-acyltransferase (MBOAT), is required for the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion and activity. Wnt signaling is dysregulated in a variety of cancers and plays a key role in cancer cell survival.",
  "synonyms": [
    "PORCN inhibitor XNW7201"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/porcupine-inhibitor-xnw7201/"
}