porcupine inhibitor ETC-1922159

{
  "id": "MLC-T-ONC-016183",
  "term": "porcupine inhibitor ETC-1922159",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of the membrane-bound O-acyltransferase (MBOAT) porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, ETC-1922159 binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational palmitoylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. Porcupine catalyzes the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion. Wnt signaling is dysregulated in a variety of cancers.",
  "synonyms": [
    "PORCN inhibitor ETC-1922159"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/porcupine-inhibitor-etc-1922159/"
}