Porcupine inhibitor WNT974

{
  "id": "MLC-T-ONC-016185",
  "term": "Porcupine inhibitor WNT974",
  "field": "Oncology and biomedicine",
  "definition": "An orally available inhibitor of porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, WNT974 binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational acylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. Porcupine, a membrane-bound O-acyltransferase (MBOAT), is required for the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion and activity. Wnt signaling is dysregulated in a variety of cancers.",
  "synonyms": [
    "LGK974",
    "PORCN inhibitor LGK974"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/porcupine-inhibitor-wnt974/"
}