germline mutation

{
  "id": "MLC-T-ONC-003526",
  "term": "germline mutation",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A gene change in a body's reproductive cell (egg or sperm) that becomes incorporated into the DNA of every cell in the body of the offspring. Germline mutations are passed on from parents to offspring. Also called germline variant.",
    "A mutation in a reproductive cell (egg or sperm) that is in the DNA of every cell in the offspring's body. A mutation contained within the germline can be passed from parent to offspring and is, therefore, hereditary. Also called germline variant."
  ],
  "synonyms": [
    "germline variant"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "NCI Dictionary of Genetics Terms"
  ],
  "url": "https://mlchart.com/terminology/oncology/germline-mutation/"
}