Gilteritinib fumarate

{
  "id": "MLC-T-ONC-003545",
  "term": "Gilteritinib fumarate",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat adults with acute myeloid leukemia that came back or did not get better with other treatment and has a mutation (change) in the FLT3 gene. Gilteritinib fumarate blocks certain proteins, which may help keep cancer cells from growing. It is a type of tyrosine kinase inhibitor. Also called Xospata.",
    "The fumarate salt form of gilteritinib, an orally bioavailable inhibitor of the receptor tyrosine kinases (RTKs) FMS-like tyrosine kinase 3 (FLT3; STK1; FLK2), AXL (UFO; JTK11), anaplastic lymphoma kinase (ALK; CD246), and leukocyte receptor tyrosine kinase (LTK), with potential antineoplastic activity. Upon administration, gilteritinib binds to and inhibits both the wild-type and mutated forms of FLT3, AXL, ALK and LTK. This may result in an inhibition of FLT3-, AXL-, ALK-, and LTK-mediated signal transduction pathways and reduced proliferation in cancer cells that overexpress these RTKs. FLT3, AXL, ALK, and LTK, which are overexpressed or mutated in a variety of cancer cell types, play key roles in tumor cell growth and survival."
  ],
  "synonyms": [
    "Xospata",
    "gilteritinib hemifumarate"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gilteritinib-fumarate/"
}