Glucarpidase

{
  "id": "MLC-T-ONC-003579",
  "term": "Glucarpidase",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat toxic levels of the anticancer drug methotrexate in the blood of adults and children with kidney problems. Glucarpidase is a bacterial enzyme that helps break down and remove methotrexate from the body. It may also help certain drugs kill cancer cells. Glucarpidase is a type of chemoprotective agent and a type of prodrug activator. Also called carboxypeptidase-G2 and Voraxaze.",
    "A zinc-dependent enzyme isolated from a strain of the bacterium Pseudomonas. Because glucarpidase rapidly hydrolyzes methotrexate into inactive metabolites, it may be useful as a rescue agent for methotrexate-induced nephrotoxicity. In antibody-directed enzyme prodrug therapy (ADEPT), this agent is conjugated with an antibody that binds to a specific tumor cell type, allowing for glucarpidase-catalyzed activation of a co-administered prodrug at the site of the tumor."
  ],
  "abbreviation": "CPG2",
  "synonyms": [
    "carboxypeptidase-G2",
    "Voraxaze"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/glucarpidase/"
}