HDAC/EGFR/Her2 inhibitor CUDC-101

{
  "id": "MLC-T-ONC-014069",
  "term": "HDAC/EGFR/Her2 inhibitor CUDC-101",
  "field": "Oncology and biomedicine",
  "definition": "A multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity. HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown. This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous, synergistic inhibition of EGFR, Her2, and HDAC.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/hdac-egfr-her2-inhibitor-cudc-101/"
}