heat-killed bacterium Mycobacterium obuense IMM-101

{
  "id": "MLC-T-ONC-014072",
  "term": "heat-killed bacterium Mycobacterium obuense IMM-101",
  "field": "Oncology and biomedicine",
  "definition": "A suspension of heat-killed Mycobacterium (M.) obuense, a non-pathogenic and naturally-occurring bacterium, with potential immunomodulating and antineoplastic activities. Upon intradermal administration of heat-killed M. obuense IMM-101, the bacteria are able to activate the innate and adaptive immune system. Specifically, IMM-101 activates immature dendritic cells (DCs), which leads to the induction of a type-1 immune response (cDC1). This may induce a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. It also activates macrophages and natural killer cells (NKs), gamma delta T (gdT) cells, and induces a type 1 T helper (Th1) cell immune response against cancer cells.",
  "synonyms": [
    "heat-killed mycobacterial product IMM-101",
    "heat-killed Mycobacterium obuense NCTC 13365 IMM-101"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/heat-killed-bacterium-mycobacterium-obuense-imm-101/"
}