HER-2/neu intracellular domain protein

{
  "id": "MLC-T-ONC-014099",
  "term": "HER-2/neu intracellular domain protein",
  "field": "Oncology and biomedicine",
  "definition": "The cytoplasmic domain or intracellular domain (ICD) of the HER2/neu protein that exhibits tyrosine kinase activity. Based on sensitization theory, co-administration of trastuzumab (anti-HER-2/neu monoclonal antibody) and HER-2/neu intracellular domain protein may result in the potentiation of a HER2/neu-specific cytotoxic T lymphocyte (CTL) response against tumor cells overexpressing the HER2/neu protein. HER-2/neu protein, a glycoprotein cell surface receptor that is composed of an extracellular domain (ECD), a transmembrane domain, and an ICD, is overexpressed by many adenocarcinomas including breast adenocarcinoma.",
  "synonyms": [
    "HER-2 ICD peptide",
    "HER-2/neu ICD protein",
    "HER2 ICD",
    "HER2 intracellular domain"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/her-2-neu-intracellular-domain-protein/"
}