pNGVL3-hICD vaccine AST-301

{
  "id": "MLC-T-ONC-016129",
  "term": "pNGVL3-hICD vaccine AST-301",
  "field": "Oncology and biomedicine",
  "definition": "A plasmid DNA therapeutic cancer vaccine encoding the intracellular domain (ICD) of the HER-2/neu proto-oncogene, with potential immunomodulating and antineoplastic activities. Upon administration, the pNGVL3-hICD vaccine AST-301 expresses the HER-2/neu protein and elicits a HER-2-specific cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing HER-2. The HER-2/neu ICD protein is highly immunogenic and, as a subdominant epitope, may be associated with decreased immune tolerance.",
  "synonyms": [
    "HER-2/neu ICD therapeutic cancer vaccine AST-301",
    "plasmid DNA-based vaccine expressing HER2/neu ICD AST-301",
    "pNGVL3-hICD plasmid DNA-based vaccine AST-301",
    "therapeutic cancer vaccine AST-301"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pngvl3-hicd-vaccine-ast-301/"
}