anti-IGFBP2 plasmid DNA vaccine AST-201

{
  "id": "MLC-T-ONC-010807",
  "term": "anti-IGFBP2 plasmid DNA vaccine AST-201",
  "field": "Oncology and biomedicine",
  "definition": "A polyepitope plasmid DNA therapeutic cancer vaccine containing the mammalian expression vector pUMVC3 encoding multiple epitopes derived from tumor-associated antigens (TAAs): human insulin-like growth factor-binding protein 2 (IGFBP2), with potential immunostimulating and antineoplastic activities. Upon intradermal vaccination, anti-IGFBP2 plasmid DNA vaccine AST-201 enters cells which process the plasmid, and express the epitopes and present them to antigen-presenting cells (APCs). This activates the immune system to mount a combined response from specific T-helper type 1 (Th1) cells, memory T-cells and cytotoxic T lymphocytes (CTL) against IGFBP2-expressing tumor cells. IGFBP2, overexpressed in certain tumor cell types, plays a key role in cellular proliferation and survival.",
  "synonyms": [
    "IGFBP2 vaccine AST201",
    "therapeutic cancer vaccine AST-201",
    "pUMVC3-hIGFBP-2-based vaccine AST201",
    "pUMVC3-hIGFBP-2 multi-epitope plasmid DNA vaccine AST201"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-igfbp2-plasmid-dna-vaccine-ast-201/"
}